4-Amino-3-nitrobenzimidamide hydrochloride → 3,4-Diaminobenzimidamide hydrochloride

HRID 1026196Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1026196
[ClH:1].[NH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[NH:8])=[CH:5][C:4]=1[N+:12]([O-])=O>[OH-].[OH-].[Pd+2].CO>[ClH:1].[NH2:12][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:3]=1[NH2:2])[C:7]([NH2:9])=[NH:8]

Komponenten

4

Edukt 1

HCID 673560924-Amino-3-nitrobenzimidamide hydrochloride

Produkt 1

HCID 221255323,4-Diaminobenzimidamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysator2×HCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 4-amino-3-nitrobenzamidine monohydrochloride (15 g, 69 mmol) and Pearlman's catalyst [Pd(OH)2, 1.0 g, 7.12 mmol) in methanol (200 mL) was shaken under hydrogen atmosphere 50 psi for 1.5 h. The suspension was filtered through Celite and the filtrate was added dropwise to anhydrous diethyl ether (400 mL) to precipitate 3,4-diaminobenzamidine monohydrochloride as a tan solid.

Aufarbeitung

  1. filtrationThe suspension was filtered through Celite
  2. additionthe filtrate was added dropwise to anhydrous diethyl ether (400 mL)
  3. customto precipitate 3,4-diaminobenzamidine monohydrochloride as a tan solid

Quellen und Nachweise

ORD-Eintrag
ord-ff68b3688fc54bdbb19cd8204f84dc29
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08729117B2

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