(Z)-Prop-1-en-1-ylboronic acid → cis-2-benzyl-3a-methyl-6-((Z)-prop-1-enyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindole

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Tetrakis(triphenylphosphine)Pd(0) (0.021 mmol, 24.32 mg) was added in one portion to a mixture of cis-2-benzyl-6-bromo-3a-methyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindole (0.421 mmol, 150 mg) and (Z)-prop-1-enylboronic acid (0.631 mmol, 54.2 mg) in 2 N aq Na2CO3 (1 ml), DME (1 ml) and EtOH (0.5 ml) The reaction mixture was heated under microwave irradiation at 160° C. for 900 seconds and then the mixture was filtered through celite. The resulting filtrate was diluted with water and extracted with DCM (3×). The combined organic extracts were dried over Na2SO4 and conc in vauco to afford a brown oil that was purified by silica column chromatography (eluting with 10% EtOAc in heptane) to afford cis-2-benzyl-3a-methyl-6-((Z)-prop-1-enyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindole) (127 mg), m/z: 318.3 [M+H]+.

Herkunft & Nachweise