Hydrochloric Acid → 2-{2-Fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohexyl]-phenyl}-2,8-diaza-spiro[4.5]decan-1-one hydrochloride

HRID 1027431Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1027431
C(OC([N:8]1[CH2:37][CH2:36][C:11]2([C:15](=[O:16])[N:14]([C:17]3[CH:22]=[CH:21][C:20]([CH:23]4[CH2:28][CH2:27][CH:26]([N:29]5[CH2:33][CH2:32][CH2:31][C@@H:30]5[CH3:34])[CH2:25][CH2:24]4)=[CH:19][C:18]=3[F:35])[CH2:13][CH2:12]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:38]>CO.O1CCOCC1>[ClH:38].[F:35][C:18]1[CH:19]=[C:20]([CH:23]2[CH2:28][CH2:27][CH:26]([N:29]3[CH2:33][CH2:32][CH2:31][C@@H:30]3[CH3:34])[CH2:25][CH2:24]2)[CH:21]=[CH:22][C:17]=1[N:14]1[CH2:13][CH2:12][C:11]2([CH2:10][CH2:9][NH:8][CH2:37][CH2:36]2)[C:15]1=[O:16]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 545919182-{2-Fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohexyl]-phenyl}-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester

Produkt 1

HCID 545919192-{2-Fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohexyl]-phenyl}-2,8-diaza-spiro[4.5]decan-1-one hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

2-{2-Fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohexyl]-phenyl}-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester was dissolved in 0.5 mL of methanol and cooled to ice-water bath. To this solution was added 0.5 mL of 4M HCl in dioxane (excess). The clear solution was stirred at r.t. overnight. The solvent was evaporated and the residue was further dried under reduced pressure to obtain the title compound as a gummy semi-solid.

Aufarbeitung

  1. temperaturecooled to ice-water bath
  2. customThe solvent was evaporated
  3. customthe residue was further dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-90234667d1214e2493ee77c321659dab
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735385B2

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