Hexyl isocyanate → HCID 131731416, Verbindung
Reaktionsgleichung
[C:1]1(=[O:11])[CH:5]2[CH2:6][CH2:7][CH2:8][CH2:9][N:4]2[C:3](=[O:10])[NH:2]1.N(CCCCCC)=[C:13]=O>O1CCOCC1>[O:11]=[C:1]1[CH:5]2[CH2:6][CH2:7][CH2:8][CH2:9][N:4]2[C:3](=[O:10])[NH:2]1.[CH3:13][CH:5]([C:1]([NH2:2])=[O:11])[CH2:6][CH2:7][CH2:8][CH3:9]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Tetrahydroimidazo[1,5-a]pyridine-1,3-dione (690 mg, 4.476 mmol) and isocyanato-hexane (1.5 ml, 10.3 mmol, addition in several portions) were stirred in 30 ml of dioxane at 80° C. for 3 h and at 110° C. for 5 h. Concentration was followed by purification by preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 23 mg (2%), M+H+:282.20.
Aufarbeitung
- concentrationConcentration
- customwas followed by purification by preparative HPLC (PR18, acetonitrile/water 0.1% TFA)
Quellen und Nachweise
- ORD-Eintrag
- ord-f8f8eb1301ab481caa01a3e37e868018
- Quelldatensatz
- uspto-grants-2014_05
- Patentnummer
- US08735437B2
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