Hydrochloric Acid → Methyl 2-(4-oxocyclohexyl)acetate

HRID 1028200

Reaktionsgleichung

Reaktionsgleichung von HRID 1028200
Cl.[CH3:2][O:3][C:4](=[O:16])[CH2:5][CH:6]1[CH2:15][CH2:14][C:9]2(OCC[O:10]2)[CH2:8][CH2:7]1>CC(C)=O>[CH3:2][O:3][C:4](=[O:16])[CH2:5][CH:6]1[CH2:15][CH2:14][C:9](=[O:10])[CH2:8][CH2:7]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 20711792Methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate

Produkt 1

HCID 21249113Methyl 2-(4-oxocyclohexyl)acetateAusbeute 108,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A 1 N aqueous hydrochloric acid solution (50 mL)/acetone (200 ml) mixture of (1,4-dioxa-spiro[4.5]dec-8-yl)-acetic acid methyl ester (4.99 g) obtained in Example (1b) was stirred at room temperature for 15 hours. The organic solvent was removed using an evaporator. The remaining aqueous solution was subjected to two extractions with ethyl acetate. The organic layer was washed with saturated brine, then dried over sodium sulfate, and then concentrated to obtain the title compound (4.30 g, quantitative yield) as a colorless oil.

Aufarbeitung

  1. customThe organic solvent was removed
  2. customan evaporator
  3. extractionThe remaining aqueous solution was subjected to two extractions with ethyl acetate
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-fb35a696927b494fbeb28c853f0474a5
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735425B2

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