2-Oxobutanoic Acid → ethyl acetoacetate, sodium salt

HRID 1028407

Reaktionsgleichung

Reaktionsgleichung von HRID 1028407
[O:1]=[C:2]([CH2:6][CH3:7])[C:3]([OH:5])=[O:4].O.[C:9]1(C)C=CC(S(O)(=O)=O)=C[CH:10]=1>C(O)C>[CH2:9]([O:4][C:3](=[O:5])[C:2](=[O:1])[CH2:6][CH3:7])[CH3:10]

Komponenten

4

Edukt 2

HCID 582-Oxobutanoic AcidHCID 521998p-Toluenesulfonic acid monohydrate

Produkt 1

HCID 85195ethyl acetoacetate, sodium saltAusbeute 16.662,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2-Oxo-butyric acid (10.0 g, 97.2 mmol) was dissolved in ethanol (100 mL) and p-toluene sulfonic acid mono hydrate (0.1 g) was added. The reaction mixture was heated to reflux for 48 h. After cooling the reaction mixture to room temperature, the ethanol was removed under reduced pressure to give 11.4 g of 2-oxo-butyric acid ethyl ester.

Aufarbeitung

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 48 h
  3. customthe ethanol was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1067fd82c6ef4ddeb78934f25c0d7c54
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735588B2

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