Hydrochloric Acid → HCID 71253315, Verbindung

Reaktionsgleichung

[NH2:1][C:2]1[C:11]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:18]3[C:27]([CH2:28][CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:26][CH:25]=[CH:24][C:19]=3[C:20]([O:22]C)=[O:21])[CH:8]=2)[N:3]=1.[OH-].[Na+].[ClH:36]>CO>[ClH:36].[NH2:1][C:2]1[C:11]([N:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:18]3[C:27]([CH2:28][CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:26][CH:25]=[CH:24][C:19]=3[C:20]([OH:22])=[O:21])[CH:8]=2)[N:3]=1

Komponenten

Versuchsvorschrift

A solution of methyl 2-(2-amino-3-morpholinoquinolin-6-yl)-3-(3,3-dimethylbutyl)benzoate (520 mg, 1.162 mmol) in MeOH (20 mL) and 5N NaOH (0.929 mL, 4.65 mmol) was heated to 80° C. for 7 h. The solution was cooled to RT and acidified with 5N HCl to pH of ˜4. The solution was concentrated under reduced pressure. The residue was dissolved in MeOH and filtered. The filtrate was concentrated under reduced pressure to yield 2-(2-amino-3-morpholinoquinolin-6-yl)-3-(3,3-dimethylbutyl)benzoic acid hydrochloride as a brown solid which was used without further purification.