4-Methylpiperazine-1-ethylamine → 1-(4-Benzamidophenylamino)-N-(2-(4-methylpiperazin-1-yl)ethyl)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-8-carboxamide

HRID 1029229

Reaktionsgleichung

Reaktionsgleichung von HRID 1029229
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17]2[CH:26]=[CH:25][N:24]=[C:23]3[C:18]=2[C:19]2[CH:31]=[CH:30][C:29]([C:32](O)=[O:33])=[CH:28][C:20]=2[C:21](=[O:27])[NH:22]3)=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:35][N:36]1[CH2:41][CH2:40][N:39]([CH2:42][CH2:43][NH2:44])[CH2:38][CH2:37]1>>[C:1]([NH:9][C:10]1[CH:11]=[CH:12][C:13]([NH:16][C:17]2[CH:26]=[CH:25][N:24]=[C:23]3[C:18]=2[C:19]2[CH:31]=[CH:30][C:29]([C:32]([NH:44][CH2:43][CH2:42][N:39]4[CH2:40][CH2:41][N:36]([CH3:35])[CH2:37][CH2:38]4)=[O:33])=[CH:28][C:20]=2[C:21](=[O:27])[NH:22]3)=[CH:14][CH:15]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 702844-Methylpiperazine-1-ethylamineHCID 442055041-(4-Benzamidophenylamino)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-8-carboxylic acid

Produkt 1

HCID 442055071-(4-Benzamidophenylamino)-N-(2-(4-methylpiperazin-1-yl)ethyl)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-8-carboxamide

Versuchsvorschrift

The title compound was synthesized according to the procedure described for the preparation of Example 269 using 268 (30 mg, 0.07 mmol) and 2-(4-methyl-piperazin-1-yl)-ethylamine to provide 271. LC-MS (M+H=576, obsd.=576).

Aufarbeitung

  1. customThe title compound was synthesized

Quellen und Nachweise

ORD-Eintrag
ord-8bd38ec220c54f968f4f67fd76263cab
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735584B2

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