Benzamide, N-(4-aminophenyl)- → N-(4-(8-Chloro-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-ylamino)phenyl)benzamide

HRID 1029233

Reaktionsgleichung

Reaktionsgleichung von HRID 1029233
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:33])[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:21][CH:20]=1>>[Cl:17][C:14]1[CH:15]=[CH:16][C:4]2[C:3]3[C:8](=[N:9][CH:10]=[CH:11][C:2]=3[NH:18][C:19]3[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:33])[C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)=[CH:21][CH:20]=3)[NH:7][C:6](=[O:12])[C:5]=2[CH:13]=1

Komponenten

3

Edukt 2

HCID 87196Benzamide, N-(4-aminophenyl)-HCID 698100241,8-dichloro-5H-benzo[c][1,8]naphthyridin-6-one

Produkt 1

HCID 44205715N-(4-(8-Chloro-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-ylamino)phenyl)benzamide

Versuchsvorschrift

The title compound was synthesized according to the procedure described for the preparation of Example 267 using 1,8-dichloro-5H-benzo[c][1,8]naphthyridin-6-one and N-(4-aminophenyl)benzamide to provide 275. LC-MS (M+H=442, obsd.=442).

Aufarbeitung

  1. customThe title compound was synthesized

Quellen und Nachweise

ORD-Eintrag
ord-8020402224434897941985ae40b73c16
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735584B2

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