N-(4-Aminophenyl)-3,4-difluoro-benzamide → 1-(4-(3,4-Difluorobenzamido)phenylamino)-N-(2-(dimethylamino)ethyl)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-9-carboxamide

HRID 1029239Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1029239
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[C:15]([C:17]([NH:19][CH2:20][CH2:21][N:22]([CH3:24])[CH3:23])=[O:18])[CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([NH:32][C:33](=[O:42])[C:34]2[CH:39]=[CH:38][C:37]([F:40])=[C:36]([F:41])[CH:35]=2)=[CH:28][CH:27]=1>>[F:41][C:36]1[CH:35]=[C:34]([CH:39]=[CH:38][C:37]=1[F:40])[C:33]([NH:32][C:29]1[CH:28]=[CH:27][C:26]([NH:25][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[C:15]([C:17]([NH:19][CH2:20][CH2:21][N:22]([CH3:24])[CH3:23])=[O:18])[CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)=[CH:31][CH:30]=1)=[O:42]

Komponenten

3

Edukt 2

HCID 20115387N-(4-Aminophenyl)-3,4-difluoro-benzamideHCID 698106731-Chloro-N-(2-(dimethylamino)ethyl)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-9-carboxamide

Produkt 1

HCID 442063901-(4-(3,4-Difluorobenzamido)phenylamino)-N-(2-(dimethylamino)ethyl)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-9-carboxamide

Versuchsvorschrift

The title compound was synthesized according to the procedure described for the preparation of Example 267 using 296 (40 mg, 0.12 mmol), and N-(4-amino-phenyl)-3,4-difluoro-benzamide (36 mg, 0.12 mmol) to provide 298. LC-MS (M+H=557, obsd.=557).

Aufarbeitung

  1. customThe title compound was synthesized

Quellen und Nachweise

ORD-Eintrag
ord-9675bcbe0d2c4024a586bfdc026ddcaa
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735584B2

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