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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1029262Erstellt: 26. Oktober 2026

Benzamide, N-(4-aminophenyl)- → N-[4-(9-Trifluoromethyl-6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-ylamino)-phenyl]-benzamide

https://huagongshe.com/reaction/1029262

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktBenzamide, N-(4-aminophenyl)-HCID 87196—
Edukt1-chloro-9-trifluoromethyl-5H-benzo[c][1,8]naphthyridin-6-oneHCID 68648817—
ProduktN-[4-(9-Trifluoromethyl-6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-ylamino)-phenyl]-benzamideHCID 44208006—

Reaktionsschritte

The title compound was synthesized according to the procedure described for the preparation of Example 378, method 2 using 1-chloro-9-trifluoromethyl-5H-benzo[c][1,8]naphthyridin-6-one and N-(4-amino-phenyl)-benzamide to provide 403. LC-MS (M+H=475, obsd.=475). 1H NMR (400 MHz, DMSO-d6): δ 6.96 (d, 1H), 7.18 (d, 2H), 7.54 (m, 3H), 7.76 (m, 2H), 7.78 (d, 1H), 7.97 (d, 1H), 8.10 (d, 1H), 8.27 (s, 1H), 8.85 (d, 1H), 8.99 (s, 1H), 10.25 (s, 1H).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08735584B2
Quelldatensatzuspto-grants-2014_05
ORD IDord-2e6199cc19dd47cdbc511c14cde2d138
Quellennotizuspto-grants-2014_05