[5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid → HCID 58167980, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1I.[F:10][C:11]1[CH:12]=[CH:13][C:14]([C:20](OC)=[O:21])=[C:15](B(O)O)[CH:16]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[C:3]=1[C:13]1[CH:12]=[C:11]([F:10])[CH:16]=[CH:15][C:14]=1[C:20](=[O:21])[NH:8]2Komponenten
3
Versuchsvorschrift
The title compound was synthesized according to the procedure described for the preparation of Example 1 using 4-chloro-3-iodopyridin-2-amine (1.20 g, 4.72 mmol) and 5-fluoro-2-methoxycarbonylphenylboronic acid (1.03 g, 5.19 mmol) to provide 410 (250 mg, 21% yield) as a solid. LC-MS (M+H=249, obsd.=249).
Aufarbeitung
- customThe title compound was synthesized
Quellen und Nachweise
- ORD-Eintrag
- ord-4fc0e2d2e2c14e918ad31f629431d5b2
- Quelldatensatz
- uspto-grants-2014_05
- Patentnummer
- US08735584B2
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