Reaktionsgleichung
[NH2:1][C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3.Br[CH2:18][C:19]1[C:24]([C:25]([F:28])([F:27])[F:26])=[CH:23][CH:22]=[CH:21][C:20]=1[F:29]>>[F:29][C:20]1[CH:21]=[CH:22][CH:23]=[C:24]([C:25]([F:26])([F:27])[F:28])[C:19]=1[CH2:18][NH:1][C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3Komponenten
3
Versuchsvorschrift
The title compound was synthesized according to the procedure described for the preparation of Example 458 using 70 (122 mg, 0.58 mmol) and 2-(bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene (179 mg, 0.70 mmol) to provide 461 (12 mg, 5% yield) as a white powder. LC-MS (M+H=388, obsd.=388). 1H NMR (400 MHz, DMSO-D6) δ 8.53 (dd, J=1.7, 8.0, 1H), 8.43 (dd, J=1.6, 4.7, 1H), 8.00 (d, J=8.7, 1H), 7.95 (s, 1H), 7.63 (d, J=7.8, 1H), 7.46 (dd, J=8.1, 13.2, 1H), 7.40 (d, J=2.1, 1H), 7.32 (dd, J=4.7, 7.9, 2H), 6.88 (dd, J=2.0, 8.7, 1H), 6.20 (s, 2H), 5.90 (s, 1H).
Aufarbeitung
- customThe title compound was synthesized
Quellen und Nachweise
- ORD-Eintrag
- ord-5dfb5a0e58b547a28c41d1b71b9c6beb
- Quelldatensatz
- uspto-grants-2014_05
- Patentnummer
- US08735584B2
Verknüpfte Notizen
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