Sodium Cyanide → 2-Amino-3-(5-methoxy-3-indolyl)-propionitrile
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][C:13]#[N:14].[C-:15]#[N:16].[Na+]>CN(C)C=O>[NH2:14][CH:13]([CH2:12][C:6]1[C:5]2[C:9](=[CH:10][CH:11]=[C:3]([O:2][CH3:1])[CH:4]=2)[NH:8][CH:7]=1)[C:15]#[N:16]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Using the same method starting from 5.4 millimoles (1 g ) of (5-methoxy-3-indolyl)-acetonitrile and replacing of cyanising agent by 20 ml of a norma1 solution of sodium cyanide in dimethylformamide, there are obtained, after purification by an acid-base extraction, 0.50 g of 2-amino-3-(5-methoxy-3-indolyl)-propionitrile with a yield of 43%.
Aufarbeitung
- customare obtained
- customafter purification
- extractionby an acid-base extraction, 0.50 g of 2-amino-3-(5-methoxy-3-indolyl)-propionitrile with a yield of 43%
Quellen und Nachweise
- ORD-Eintrag
- ord-60fb506131a64b6ab287f55d11c56850
- Quelldatensatz
- uspto-grants-1992_04
- Patentnummer
- US05103019
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