Thionyl Chloride → 2-Chloro-4-methylthiazole-5-carboxylic acid chloride
Reaktionsgleichung
[Cl:1][C:2]1[S:3][C:4]([C:8]([OH:10])=O)=[C:5]([CH3:7])[N:6]=1.S(Cl)([Cl:13])=O>CN(C)C=O>[Cl:1][C:2]1[S:3][C:4]([C:8]([Cl:13])=[O:10])=[C:5]([CH3:7])[N:6]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
8.8 g of 2-chloro-4-methylthiazole-5-carboxylic acid was suspended in 7 ml of thionyl chloride, and one drop of N,N-dimethylformamide was added. The mixture was heated under reflux for 1 hour, and then the excess of thionyl chloride was evaporated under reduced pressure. Benzene (10 ml) was added, and the mixture was evaporated under reduced pressure. This procedure was repeated three times to give 9.7 g of 2-chloro-4-methylthiazole-5-carboxylic acid chloride which was used in the following reaction without purification.
Aufarbeitung
- temperatureThe mixture was heated
- temperatureunder reflux for 1 hour
- customthe excess of thionyl chloride was evaporated under reduced pressure
- additionBenzene (10 ml) was added
- customthe mixture was evaporated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-9526b21a2f9149768b8fd585de14c167
- Quelldatensatz
- uspto-grants-1992_04
- Patentnummer
- US05104886
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