Hydrogen Sulfide → 3,5-Di-tert-butyl-4-hydroxyphenyl thioacetamide

HRID 1030226

Reaktionsgleichung

Reaktionsgleichung von HRID 1030226
[C:1]([C:5]1[CH:6]=[C:7]([CH2:16][C:17]#[N:18])[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[SH2:26]>N1C=CC=CC=1>[C:12]([C:9]1[CH:8]=[C:7]([CH2:16][C:17]([NH2:18])=[S:26])[CH:6]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[C:10]=1[OH:11])([CH3:15])([CH3:14])[CH3:13]

Komponenten

5

Edukt 3

HCID 402Hydrogen SulfideHCID 8471TriethylamineHCID 615568(3,5-Di-tert-butyl-4-hydroxyphenyl)acetonitrile

Produkt 1

HCID 146278133,5-Di-tert-butyl-4-hydroxyphenyl thioacetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

3,5-Di-tert-butyl-4-hydroxyphenylacetonitrile (20.0 g) and 11.4 ml of triethylamine were dissolved in 40 ml of pyridine, and hydrogen sulfide was blown into the solution at room temperature over 13 hours. The reaction mixture was concentrated, and the crude product thus obtained was purified by silica gel column chromatography (diethyl ether-hexane =3:7) to give 4.9 g of the desired compound as a colorless solid.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. customthe crude product thus obtained
  3. customwas purified by silica gel column chromatography (diethyl ether-hexane =3:7)

Quellen und Nachweise

ORD-Eintrag
ord-233302ed76be423e8e7ebd794f843162
Quelldatensatz
uspto-grants-1992_04
Patentnummer
US05104889

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