Hydrochloric Acid → HCID 19744875, Verbindung

HRID 1030729Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1030729
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([C:11](=[O:22])[CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[C:5]([O:23][CH2:24][C:25]([O:27]C)=[O:26])[CH:4]=1.[OH-].[K+].Cl>CO>[C:25]([CH2:24][O:23][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([O:9][CH3:10])[C:6]=1[C:11](=[O:22])[CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=1)([OH:27])=[O:26]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19744869HCID 19744869, Verbindung

Produkt 1

HCID 19744875HCID 19744875, VerbindungAusbeute 87,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Then, 6.05 g of 1-(4,6-dimethoxy-2-methoxycarbonylmethoxyphenyl)-3-(4-methoxyphenyl)-1-propanone was dissolved in 50 ml of methanol, and 30 ml of a 5% aqueous solution of potassium hydroxide was added to the solution and the mixture was stirred at room temperature for 30 minutes to effect reaction. After the reaction, the reaction mixture was made acidic by addition of dilute hydrochloric acid, extracted with diethyl ether and filtered, and the solvent was removed from the filtrate by distillation and the obtained residue was recrystallized from a mixed solvent of diethyl ether and n-hexane to obtain 5.0 g (yield=87.4%) of 1-(2-carboxymethoxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-propanone in the form of a colorless prism.

Aufarbeitung

  1. customreaction
  2. customAfter the reaction
  3. extractionextracted with diethyl ether
  4. filtrationfiltered
  5. customthe solvent was removed from the filtrate by distillation
  6. customthe obtained residue was recrystallized from a mixed solvent of diethyl ether and n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-4968ef7e55944f3e9a8b281894d315b4
Quelldatensatz
uspto-grants-1992_04
Patentnummer
US05106871

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