Methyl iodide → 5,7,N-trimethyl-N-(2,6-dichlorophenyl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide

HRID 1031369Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1031369
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[C:10]([S:12]([NH:15][C:16]3[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:23])(=[O:14])=[O:13])[N:11]=[C:4]2[N:3]=1.[CH3:24]C(C)([O-])C.[K+].CI>C(#N)C.C(Cl)Cl>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[C:10]([S:12]([N:15]([CH3:24])[C:16]3[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:23])(=[O:13])=[O:14])[N:11]=[C:4]2[N:3]=1

Komponenten

6

Edukt 3

HCID 6328Methyl iodideHCID 179147Xrd 489HCID 23665647Potassium tert-butoxide

Produkt 1

HCID 141553575,7,N-trimethyl-N-(2,6-dichlorophenyl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamideAusbeute 51,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6342AcetonitrileLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 3.00 g (8.06 mmol) of 5,7-dimethyl-N-(2,6-dichlorophenyl)-1,2,4-triazolo[1,5-a]-pyrimidine-2-sulfonamide and 0.90 g (8.1 mmol) of potassium t-butoxide in 30 ml of acetonitrile was heated at reflux for 40 minutes. After cooling to room temperature 1.14 g (8.06 mmol) of methyl iodide was added, and the reaction was heated at reflux for 1 hour. After cooling to room temperature, the reaction mixture was diluted with methylene chloride and washed with 1% aqueous NaOH. The organic phase was separated, dried (MgSO4) and evaporated at reduced pressure. The brown solid residue was recrystallized from acetone to give 1.60 g (51%) the desire product as a tan solid, mp 220°-222° C. IR and 1H NMR spectra were in agreement with the assigned structure.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 40 minutes
  3. additionwas added
  4. temperaturethe reaction was heated
  5. temperatureat reflux for 1 hour
  6. washwashed with 1% aqueous NaOH
  7. customThe organic phase was separated
  8. dry with materialdried (MgSO4)
  9. customevaporated at reduced pressure
  10. customThe brown solid residue was recrystallized from acetone

Quellen und Nachweise

ORD-Eintrag
ord-c741534aaee64b8cbddfbfe6e1940d5a
Quelldatensatz
uspto-grants-1990_09
Patentnummer
US04954163

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