Sodium hydride → 4-[3-(2-(N-methylanilino)-5-pyridyl)-3-(3,4-dimethoxyphenyl)acryloyl]morpholine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Sodium hydride	HCID 24758	—
Edukt	Phosphonic acid, [2-(4-morpholinyl)-2-oxoethyl]-, diethyl ester	HCID 11207805	—
Edukt	5-(3,4-dimethoxybenzoyl)-2-(N-methylanilino)pyridine	HCID 14878865	—
Produkt	4-[3-(2-(N-methylanilino)-5-pyridyl)-3-(3,4-dimethoxyphenyl)acryloyl]morpholine	HCID 53937148	32,1%

Reaktionsschritte

In the same manner as in Example 1, using 5-(3,4-dimethoxybenzoyl)-2-(N-methylanilino)pyridine (500 mg), diethylphosphonoacetic acid morpholide (800 mg) and 60% sodium hydride (150 mg), E-isomer (250 mg) and Z-isomer (212 mg) of 4-[3-(2-(N-methylanilino)-5-pyridyl)-3-(3,4-dimethoxyphenyl)acryloyl]morpholine (Compound No.62) were obtained.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04954497
Quelldatensatz	uspto-grants-1990_09
ORD ID	ord-60040d8caa1041c58f900df3b01c3d8d
Quellennotiz	uspto-grants-1990_09