HCID 13629298, Verbindung → 2-(3-Amino-4-benzyloxyphenyl)acetic acid dipropylamide

HRID 1032509Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1032509
[CH2:1]([N:4]([CH2:25][CH2:26][CH3:27])[C:5](=[O:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:9]([N+:21]([O-])=O)[CH:8]=1)[CH2:2][CH3:3].[H][H]>[Ni].CO>[CH2:25]([N:4]([CH2:1][CH2:2][CH3:3])[C:5](=[O:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:9]([NH2:21])[CH:8]=1)[CH2:26][CH3:27]

Komponenten

5

Edukt 2

HCID 13629298HCID 13629298, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 136292992-(3-Amino-4-benzyloxyphenyl)acetic acid dipropylamideAusbeute 73,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

In the presence of Raney nickel, 36.0 g of 2-(4-benzyloxy-3-nitrophenyl)acetic acid dipropylamide is hydrogenated in 600 ml of methanol until 6.7 l of hydrogen has been absorbed, which takes about 4.5 hours. The crude product obtained after removing the catalyst by filtration and after evaporation is chromatographed on silica gel with cyclohexane/ethyl acetate (1:1), thus obtaining 24.4 g of pure 2-(3-amino-4-benzyloxyphenyl)acetic acid dipropylamide as an oil.

Aufarbeitung

  1. customhas been absorbed
  2. customThe crude product obtained
  3. customafter removing the catalyst
  4. filtrationby filtration
  5. customafter evaporation
  6. customis chromatographed on silica gel with cyclohexane/ethyl acetate (1:1)

Quellen und Nachweise

ORD-Eintrag
ord-738ee511f8344515839a0616d119ba45
Quelldatensatz
uspto-grants-1990_09
Patentnummer
US04958026

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