Thionyl Chloride → 4-Benzyloxy-3-nitrobenzyl chloride

HRID 1032513

Reaktionsgleichung

Reaktionsgleichung von HRID 1032513
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13]O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O>>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][Cl:22])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 13629301(4-(Benzyloxy)-3-nitrophenyl)methanol

Produkt 1

HCID 136293024-Benzyloxy-3-nitrobenzyl chloride

Versuchsvorschrift

Under agitation, 58.3 g of 4-benzyloxy-3-nitrobenzyl alcohol is introduced in incremental portions into 250 ml of thionyl chloride, stirred for 30 minutes at room temperature, and concentrated under vacuum. The residue is recrystallized from diisopropyl ether while decolorizing with active carbon, thus producing 50.9 g of 4-benzyloxy-3-nitrobenzyl chloride, mp 60°-61° C.

Aufarbeitung

  1. concentrationconcentrated under vacuum
  2. customThe residue is recrystallized from diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-f154fe0b6dc34555ac16b885a6de168a
Quelldatensatz
uspto-grants-1990_09
Patentnummer
US04958026

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