Potassium Hydroxide → HCID 14856031, Verbindung

HRID 1032696Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1032696
[OH-:1].[K+].[CH2:3]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[N:21]=[C:20]([CH2:22]Cl)[C:19]([C:24]([O:26]CC)=[O:25])=[CH:18][N:17]=2)[CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C(O)C>[CH2:3]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[N:21]=[C:20]([CH2:22][OH:1])[C:19]([C:24]([OH:26])=[O:25])=[CH:18][N:17]=2)[CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 13769878Ethyl 4-(chloromethyl)-2-[4-(phenylmethyl)-1-piperazinyl]-5-pyrimidinecarboxylate

Produkt 1

HCID 14856031HCID 14856031, VerbindungAusbeute 44,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethanol (80 ml) and 2.64 g (40.0 mmoles) of 85% potassium hydroxide were added to 5.0 g (13.3 mmoles) of ethyl 2-(4-benzylpiperazino)-4-chloromethylpyrimidine-5-carboxylate (produced in accordance with Referential Example 41 of Japanese Laid-Open Patent Publication No. 140568/1986), and the mixture was refluxed for 30 minutes. Ethanol was evaporated under reduced pressure. The residue was dissolved in water, and adjusted to pH about 4 with concentrated hydrochloric acid. The crystals that formed were collected by filtration, and washed with acetone to give 1.93 g (yield 44%) of 2-(4-benzylpiperazino)-4-hydroxymethylpyrimidine-5-carboxylic acid as crystals.

Aufarbeitung

  1. customproduced in accordance with Referential Example 41 of Japanese Laid-Open Patent Publication No
  2. temperature140568/1986), and the mixture was refluxed for 30 minutes
  3. customEthanol was evaporated under reduced pressure
  4. dissolutionThe residue was dissolved in water
  5. customThe crystals that formed
  6. filtrationwere collected by filtration
  7. washwashed with acetone

Quellen und Nachweise

ORD-Eintrag
ord-f93eced4a9424a3bbdb3a0f25d70b4d8
Quelldatensatz
uspto-grants-1990_09
Patentnummer
US04959368

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