1-(Prop-2-yn-1-yl)-1H-indole-2,3-dione → HCID 14851859, Verbindung

HRID 1032760

Reaktionsgleichung

Reaktionsgleichung von HRID 1032760
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16](I)[S:17][C:13]=2[N:12]2[C:19]([CH3:22])=[N:20][N:21]=[C:11]2[CH2:10][N:9]=1.[CH2:23]([N:26]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:28](=[O:35])[C:27]1=[O:36])[C:24]#[CH:25]>C(OCC)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:25]#[C:24][CH2:23][N:26]3[C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[C:28](=[O:35])[C:27]3=[O:36])[S:17][C:13]=2[N:12]2[C:19]([CH3:22])=[N:20][N:21]=[C:11]2[CH2:10][N:9]=1

Komponenten

4

Edukt 2

HCID 19090021-(Prop-2-yn-1-yl)-1H-indole-2,3-dioneHCID 14851924HCID 14851924, Verbindung

Produkt 1

HCID 14851859HCID 14851859, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

This compound was prepared as described in Example 37 by coupling of 4-(2-chlorophenyl)-2-iodo-9-methyl 6H-thieno[ 3,2-f][1,2,4]triazolo[4,3-a] [1,4]diazepine with 1-(2-propynyl)-1H-indole-2,3-dione [ref. A. Lindquist et al., Acta Pharm. Suecica 9, 99 (1972)]. Chromatographic isolation and crystallization from methanol/ethyl acetate gave orange crystals with m.p. 185°-190° C. with foaming at 130°-140° C. These crystals contained according to analytical and spectral data molar amounts of ethyl acetate.

Aufarbeitung

  1. customThis compound was prepared
  2. customChromatographic isolation and crystallization from methanol/ethyl acetate
  3. customgave orange crystals with m.p. 185°-190° C.
  4. customwith foaming at 130°-140° C

Quellen und Nachweise

ORD-Eintrag
ord-6be3d88cac434f668a197da86716e0d3
Quelldatensatz
uspto-grants-1990_09
Patentnummer
US04959361

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