Trifluoroacetic acid → (2R*,4S*)-2-Benzyl-N-(2-phenylethyl)-N-trifluoroacetyl-4-piperidinamine

HRID 1033352

Reaktionsgleichung

Reaktionsgleichung von HRID 1033352
[CH2:1]([C@@H:8]1[CH2:13][C@@H:12]([N:14]([CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:15](=[O:20])[C:16]([F:19])([F:18])[F:17])[CH2:11][CH2:10][N:9]1C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[CH2:1]([C@@H:8]1[CH2:13][C@@H:12]([N:14]([CH2:21][CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:15](=[O:20])[C:16]([F:19])([F:18])[F:17])[CH2:11][CH2:10][NH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 57018205(2R*,4S*)-2-Benzyl-1-t-butyloxycarbonyl-N-(2-phenylethyl)-N-trifluoroacetyl-4-piperidinamine

Produkt 1

HCID 22863105(2R*,4S*)-2-Benzyl-N-(2-phenylethyl)-N-trifluoroacetyl-4-piperidinamine

Versuchsvorschrift

615 mg (1.25 mmol) of (2R*,4S*)-2-benzyl-1-t-butyloxycarbonyl-N-(2-phenylethyl)-N-trifluoroacetyl-4-piperidinamine are reacted with 1.9 ml (25 mmol) of trifluoroacetic acid in analogy to Example 38d. The title compound is obtained as oil (308 mg, 63%). TLC: methylene chloride/methanol/conc. ammonia (700:50:1) Rf =0.63, FD-MS: M+ =390.

Quellen und Nachweise

ORD-Eintrag
ord-5ae966b8fa1b4a05912c26d89f22e29e
Quelldatensatz
uspto-grants-1994_05
Patentnummer
US05310743

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