3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid → HCID 19025659, Verbindung
Reaktionsgleichung
[C:1]([O:5][C:6]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11]([OH:13])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[CH:25][C:26]([O:28][CH3:29])=[CH:27][C:20]=2[NH:19][C:18]1=[O:30]>>[C:1]([O:5][C:6]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11]([NH:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[CH:25][C:26]([O:28][CH3:29])=[CH:27][C:20]=2[NH:19][C:18]1=[O:30])=[O:13])=[O:7])([CH3:2])([CH3:3])[CH3:4]Komponenten
3
Versuchsvorschrift
Prepared from 3-t-butoxycarbonylamino-3-methylbutanoic acid (Example 31, Step E) and the amine obtained in Step D by the procedure described in Example 1, Step F. 1H NMR (200MHz, CDCl3): 1.44 (s,6H), 1.50 (s,9H), 1.80 (m,1H), 2.80 (m,5H), 3.86 (2,3H), 4.62 (m,1H), 6.62 (d,2Hz,1H), 6.76 (dd;2,8Hz;1H), 7.20 (d,8Hz,1H). FAB-MS: calculated for C21H31N3O5 405; found 406 (M+H,42%).
Quellen und Nachweise
- ORD-Eintrag
- ord-ec565150bf7a45aab3d9f774adf1156f
- Quelldatensatz
- uspto-grants-1994_05