Methyl 4'-(bromomethyl)biphenyl-2-carboxylate → 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-carbomethoxy-[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide

HRID 1033446

Reaktionsgleichung

Reaktionsgleichung von HRID 1033446
[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:30])([CH3:29])[CH2:13][C:14]([NH:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[CH:25][CH:26]=[CH:27][C:20]=2[NH:19][C:18]1=[O:28])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:32][C:33]1[CH:38]=[CH:37][C:36]([C:39]2[C:40]([C:45]([O:47][CH3:48])=[O:46])=[CH:41][CH:42]=[CH:43][CH:44]=2)=[CH:35][CH:34]=1>>[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:30])([CH3:29])[CH2:13][C:14]([NH:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[CH:25][CH:26]=[CH:27][C:20]=2[N:19]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=3[C:45]([O:47][CH3:48])=[O:46])=[CH:35][CH:34]=2)[C:18]1=[O:28])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 11012181Methyl 4'-(bromomethyl)biphenyl-2-carboxylateHCID 218366093-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamide

Produkt 1

HCID 190256493-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-carbomethoxy-[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide

Versuchsvorschrift

Prepared from 3-benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl ]-butanamide (Example 51, Step A) and methyl 4'-bromomethyl-1,1'-biphenyl-2-carboxylate (prepared by the method of D. J. Carinie et al, EPO publication 324,377) by the procedure described in Example 1, Step K. 1H NMR (300 MHz, CDCl3): 1.37 (s,3H), 1.39 (s,3H), 1.75 (m,1H), 2.3-2.6 (m,5H), 3.52 (s,3H), 4.50 (m,1H), 4.80 (d,14Hz,1H), 5.06 (s,2H), 5.34 (d,14Hz,1H), 5.65 (s,1H), 6.72 (d,7Hz,1H), 7.1-7.4 (m,15H), 7.48 (dt;2,8Hz;1H), 7.78 (dd;2,8Hz;1H). FAB-MS: calculated for C38H39N3O6 633; found 634 (M+H,60%).

Aufarbeitung

  1. customprepared by the method of D

Quellen und Nachweise

ORD-Eintrag
ord-e1cc7d6fa3124ff5b2f80cfddd8d6624
Quelldatensatz
uspto-grants-1994_05
Patentnummer
US05310737

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