Ammonium Chloride → HCID 15341843, Verbindung

Reaktionsgleichung

[CH:1]1([CH2:4][C:5]2[C:6]([OH:16])=[C:7]([CH:12]=[CH:13][C:14]=2[OH:15])[C:8](OC)=[O:9])[CH2:3][CH2:2]1.[Cl-].[NH4+:18]>>[CH:1]1([CH2:4][C:5]2[C:6]([OH:16])=[C:7]([CH:12]=[CH:13][C:14]=2[OH:15])[C:8]([NH2:18])=[O:9])[CH2:3][CH2:2]1

Komponenten

Edukt 2

HCID 25517Ammonium Chloride

HCID 15341799HCID 15341799, Verbindung

Produkt 1

HCID 15341843HCID 15341843, Verbindung

Versuchsvorschrift

The compound of Example 15 is heated at 50° C. in a saturated ammonium chloride solution overnight. The reaction mixture is thoroughly extracted with ethyl acetate, and the solvent dried (Na2SO4) and evaporated in vacuo to afford the crude product. Chromatographic purification or silica gel using ethyl acetate/hexane (4:6) as eluant affords the product.

Aufarbeitung

extractionThe reaction mixture is thoroughly extracted with ethyl acetate
dry with materialthe solvent dried (Na2SO4)
customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-c5a247d36daf45d3b8519925f5849b6b
Quelldatensatz: uspto-grants-1994_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05310951

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