Glycidol → 3-(Octadecylamino)propane-1,2-diol

HRID 1033704

Reaktionsgleichung

Reaktionsgleichung von HRID 1033704
[CH2:1]([NH2:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH2:20]1[O:22][CH:21]1[CH2:23][OH:24]>CO>[CH2:1]([NH:19][CH2:20][CH:21]([OH:22])[CH2:23][OH:24])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Komponenten

4

Edukt 2

HCID 11164GlycidolHCID 15793Octadecylamine

Produkt 1

HCID 1200883-(Octadecylamino)propane-1,2-diolAusbeute 95,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Octadecylamine (18 g) was dissolved in 200 ml methanol and heated to 60° C. Glycidol (4.95 g) was added dropwise under constant stirring over one and half hours. The reaction mixture was kept under reflux for one additional hour, and then cooled to room temperature, and evaporated to dryness, resulting in 22 g white solid material. This was then recrystallized from hexane, to yield ODP, mp 81°-83° C.

Aufarbeitung

  1. temperatureunder reflux for one additional hour
  2. temperaturecooled to room temperature
  3. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-746ea6b2271b4d5fa8b21250df982ece
Quelldatensatz
uspto-grants-1994_05
Patentnummer
US05312617

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