Methyl iodide → (E)-2,2,2-trifluoro-N-methoxy-1-(1-methylpyridin-1-ium-3-yl)ethanimine iodide
Reaktionsgleichung
[CH3:1][O:2]/[N:3]=[C:4](\[C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)/[C:5]([F:8])([F:7])[F:6].[CH3:15][I:16]>C(#N)C>[I-:16].[CH3:1][O:2]/[N:3]=[C:4](\[C:9]1[CH:10]=[N+:11]([CH3:15])[CH:12]=[CH:13][CH:14]=1)/[C:5]([F:8])([F:6])[F:7]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
E-3-(α,α,α-Trifluoroacetyl)pyridine-O-methyl oxime (D7) (6.16 g, 0.030 mol) was treated with methyl iodide (15 ml, 0.241 mol) in acetonitrile (100 ml) at reflux for 3 h. The reaction mixture was cooled and evaporated to give a gum which was triturated with ether to give the title compound (D10) as a yellow solid (10.44 g, 100%) m.p. 119°-124° C.