Methyl iodide → 4,5-Dihydro-3,4,4-trimethyloxazolium iodide

HRID 1034314

Reaktionsgleichung

Reaktionsgleichung von HRID 1034314
[CH3:1][C:2]1([CH3:7])[CH2:6][O:5][CH:4]=[N:3]1.[CH3:8][I:9]>>[I-:9].[CH3:8][N+:3]1[C:2]([CH3:7])([CH3:1])[CH2:6][O:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 6328Methyl iodideHCID 1216304,4-Dimethyl-2-oxazoline

Produkt 1

HCID 118173244,5-Dihydro-3,4,4-trimethyloxazolium iodide

Versuchsvorschrift

To 8-phenyloctylmagnesium bromide (from 24.25 mmol of 8-phenyloctyl bromide and 21.27 mmol of magnesium) in distilled tetrahydrofuran (40 ml) was added 2-(2-methoxyphenyl)-4,4-dimethyloxazoline (17.10 mmol) [A. I. Meyers et al., J. org. Chem., 43, 1372 (1978)] in tetrahydrofuran (20 ml). After stirring for 24 hours, the reaction mixture was worked up to yield 2-12-(8-phenyloctyl)phenyl]-4,4-dimethyloxazoline as an oil. A solution of the oxazoline (11.58 mmol) in methyl iodide (20 ml) was refluxed under argon for 18 hours. Removal of the volatiles afforded the corresponding 3,4,4-trimethyloxazolinium iodide as a white solid (mp 76.5°-78° C.).

Aufarbeitung

  1. customRemoval of the volatiles

Quellen und Nachweise

ORD-Eintrag
ord-068bdcc3eccb4e118240d5f4f0f77811
Quelldatensatz
uspto-grants-1994_05
Patentnummer
US05314918

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