Triethylamine → N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(4-methoxybenzyl)-1H-pyrazole-4-carboxamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Triethylamine	HCID 8471	—
Edukt	Bis(2-oxo-3-oxazolidinyl)phosphinic chloride	HCID 152842	—
Edukt	1-[(4-methoxyphenyl)methyl]-1H-pyrazole-4-carboxylic acid	HCID 43565362	—
Edukt	5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine	HCID 60205276	—
Lösungsmittel	Dichloromethane	HCID 6344	—
Produkt	N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(4-methoxybenzyl)-1H-pyrazole-4-carboxamide	HCID 60205476	39,8%

Reaktionsschritte

A mixture of 5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine (300 mg, 1.30 mmol, Example 1, Step H), 1-(4-methoxybenzyl)-1H-pyrazole-4-carboxylic acid (636 mg, 2.74 mmol), BOP—Cl (697 mg, 2.74 mmol), and triethylamine (0.909 mL, 6.52 mmol) in DCM (5 mL) was processed as described in Example 62, Step A, to provide N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(4-methoxybenzyl)-1H-pyrazole-4-carboxamide (230 mg, 39% yield).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08545897B2
Quelldatensatz	uspto-grants-2013_10
ORD ID	ord-b9bdc677ec9747e6aca8bd5e0b4384d7
Quellennotiz	uspto-grants-2013_10