Ammonia → HCID 59548516, Verbindung

HRID 1035300Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1035300
C([O:3][C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[C:17]#[N:18])C.N>CO.[Ni]>[CH:16]1[C:11]2[C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[C:4](=[O:3])[NH:18][CH2:17][C:12]=2[CH:13]=[N:14][CH:15]=1

Komponenten

5

Edukt 2

HCID 222AmmoniaHCID 66769548HCID 66769548, Verbindung

Produkt 1

HCID 59548516HCID 59548516, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of Example 180C (29.4 g, 0.117 mol) and Raney®-nickel (30 g) in 2 L of methanol saturated with NH3 was stirred under H2 (50 psi) at 50° C. for 24 hours. After cooling and removal of the catalyst, the mixture was concentrated under reduced pressure to obtain the title compound which was used without further purification.

Aufarbeitung

  1. temperatureAfter cooling
  2. customremoval of the catalyst
  3. concentrationthe mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5066493f0c9045eb9711fc2072dcd3ae
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546377B2

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