Benzyl Bromide → 3-Benzyl-7-oxo-6,7-dihydro-5h-pyrido[3,4-d][2]benzazepin-3-ium bromide

HRID 1035301Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1035301
[CH:1]1[C:11]2[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](=[O:16])[NH:7][CH2:6][C:5]=2[CH:4]=[N:3][CH:2]=1.[CH2:17]([Br:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[Br-:24].[CH2:17]([N+:3]1[CH:2]=[CH:1][C:11]2[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](=[O:16])[NH:7][CH2:6][C:5]=2[CH:4]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Komponenten

4

Edukt 2

HCID 7498Benzyl BromideHCID 59548516HCID 59548516, Verbindung

Produkt 1

HCID 672477733-Benzyl-7-oxo-6,7-dihydro-5h-pyrido[3,4-d][2]benzazepin-3-ium bromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of Example 180D (24.6 g, 0.117 mol) and benzyl bromide (40.1 g, 0.234 mol) in 200 mL of ethanol was stirred at reflux overnight. After cooling with an ice-water bath, the solid was collected by filtration and washed with ethanol to obtain the title compound.

Aufarbeitung

  1. temperatureat reflux overnight
  2. temperatureAfter cooling with an ice-water bath
  3. filtrationthe solid was collected by filtration
  4. washwashed with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-e3ccbd4c7602404c9102c86bc83451d9
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546377B2

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