4-[3-(Dimethylamino)propoxy]benzonitrile → 4-[3-(Dimethylamino)propoxy]benzylamine

HRID 1035955Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1035955
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1>CO.[Ni]>[NH2:12][CH2:11][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:1])[CH3:15])=[CH:14][CH:13]=1

Komponenten

4

Edukt 1

HCID 118583624-[3-(Dimethylamino)propoxy]benzonitrile

Produkt 1

HCID 214653844-[3-(Dimethylamino)propoxy]benzylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

4-(3-(Dimethylamino)propoxy)benzonitrile (300 mg) in methanol (20 mL) was treated with Raney nickel (wet, 1.5 g) under H2 (30 psi) for 4 hour. The insoluble material was filtered off and the filtrate was concentrated to provide the title compound.

Aufarbeitung

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-b8d6d6004db044edbc0ea654bcd59dd4
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546399B2

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