Dichloromethane → methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetate

HRID 1036634Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1036634
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@@H:12]2[CH:20]=[CH:19][C:18]3[N:14]([C:15]4[N:29]=[CH:28][CH:27]=[CH:26][C:16]=4[C:17]=3[CH2:21][C:22]([O:24][CH3:25])=[O:23])[CH2:13]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(Cl)Cl>C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@@H:12]2[CH2:20][CH2:19][C:18]3[N:14]([C:15]4[N:29]=[CH:28][CH:27]=[CH:26][C:16]=4[C:17]=3[CH2:21][C:22]([O:24][CH3:25])=[O:23])[CH2:13]2)(=[O:9])=[O:10])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 6344DichloromethaneHCID 86655916methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-8,9-dihydropyrido[3,2-b]indolizin-5-yl)acetate

Produkt 1

HCID 86655917methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetateAusbeute 101 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-8,9-dihydropyrido[3,2-b]indolizin-5-yl)acetate (0.46 g, 1.1 mmol) in ethyl acetate (20 mL) was added under nitrogen Pd—C 10% (0.02 g, 0.19 mmol, 0.17 equiv.). After a period of 1 h under 1 atmosphere of H2, DCM was added to the reaction mixture which in turn was filtered over a micro filter and the solvents were evaporated to afford 464 mg of the title compound.

Aufarbeitung

  1. filtrationwas filtered over
  2. filtrationa micro filter
  3. customthe solvents were evaporated

Quellen und Nachweise

ORD-Eintrag
ord-b274faf302fd4292a1f1729c7c341794
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546422B2

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