HCID 71060655, Verbindung → 1-Oxo-4-pyridin-3-yl-2,7-diaza-spiro[4.5]decane-7-carboxylic acid tert-butyl ester

HRID 1036722Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1036722
C([O:3][C:4]([C:6]1([CH:19]([C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)[CH2:20][NH2:21])[CH2:11][CH2:10][CH2:9][N:8]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:7]1)=O)C>C1(C)C=CC=CC=1>[C:15]([O:14][C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C:6]2([C:4](=[O:3])[NH:21][CH2:20][CH:19]2[C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)[CH2:7]1)=[O:13])([CH3:16])([CH3:17])[CH3:18]

Komponenten

3

Edukt 1

HCID 71060655HCID 71060655, Verbindung

Produkt 1

HCID 710603511-Oxo-4-pyridin-3-yl-2,7-diaza-spiro[4.5]decane-7-carboxylic acid tert-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 3-(2-Amino-1-pyridin-3-yl-ethyl)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (2.5 g, 6.6 mmol) in toluene (21 ml) was heated at reflux overnight. The resulting mixture was concentrated in vacuo and the residue was purified by chromatography on silica eluting with 0-10% MeOH in DCM to afford the individual diastereomers as white solids:

Aufarbeitung

  1. temperatureat reflux overnight
  2. concentrationThe resulting mixture was concentrated in vacuo
  3. customthe residue was purified by chromatography on silica eluting with 0-10% MeOH in DCM
  4. customto afford the individual diastereomers as white solids

Quellen und Nachweise

ORD-Eintrag
ord-9bb109a5bd184ddf9cd0ccd46232f26a
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546416B2

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