Ethyl 4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylate → 4-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylic acid

HRID 1036993Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1036993
ClC1C=C(C2SC(C(O)=O)=CC=2C2C=CC=C(C#N)C=2)C=C(F)C=1.[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[CH:34]=[C:35]([C:46]([O:48]CC)=[O:47])[S:36][C:37]=2[C:38]2[CH:43]=[C:42]([F:44])[CH:41]=[C:40]([Cl:45])[CH:39]=2)[CH:29]=[CH:30][C:31]=1[F:32]>>[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[CH:34]=[C:35]([C:46]([OH:48])=[O:47])[S:36][C:37]=2[C:38]2[CH:43]=[C:42]([F:44])[CH:41]=[C:40]([Cl:45])[CH:39]=2)[CH:29]=[CH:30][C:31]=1[F:32]

Komponenten

3

Edukt 2

HCID 58066743Ethyl 4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylateHCID 580667575-(3-Chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

Produkt 1

HCID 580667454-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylic acid

Versuchsvorschrift

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 19A starting with the compound from Example 12A. The organic phase is concentrated and purified by flash chromatography (mobile phase: cyclohexane/ethyl acetate/ethyl acetate:methanol 1:1 gradient) on silica gel. 0.43 g (100% of theory) of the title compound are obtained.

Aufarbeitung

  1. concentrationThe organic phase is concentrated
  2. custompurified by flash chromatography (mobile phase: cyclohexane/ethyl acetate/ethyl acetate:methanol 1:1 gradient) on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-5b488de93749427cbf16c75da2d35efd
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546438B2

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