Hydrochloric Acid → HCID 86685457, Verbindung

HRID 1037078Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1037078
[OH:1][B:2]1[C:6]2[CH:7]=[C:8]([CH2:11][NH:12]C(=O)OC(C)(C)C)[CH:9]=[CH:10][C:5]=2[C:4]([CH3:21])([CH3:20])[O:3]1.[ClH:22]>CO>[ClH:22].[NH2:12][CH2:11][C:8]1[CH:9]=[CH:10][C:5]2[C:4]([CH3:21])([CH3:20])[O:3][B:2]([OH:1])[C:6]=2[CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86685463Tert-butyl (1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methylcarbamate

Produkt 1

HCID 86685457HCID 86685457, VerbindungAusbeute 67,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of crude compound tert-butyl (1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methylcarbamate (47.4 mmol) in methanol (150 mL) was added HCl (50 mL, 94.8 mmol). The reaction mixture was stirred for 16 h at rt. The solvent was removed to give compound 6-(aminomethyl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol hydrochloride (7.3 g; yield 67% over 4 steps). MS: m/z=192.1 (M+1, ESI+).

Aufarbeitung

  1. customThe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-995cfc1933b84565aa2d1a1ef4f3d2fc
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546357B2

Notizen zur Reaktion

Wird geladen…