3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-7-methoxy-6-methyl-2-phenyl-chromen-4-one
Reaktionsgleichung
NC1(C2C=CC(C3C(=O)C4C(=CC=C(F)C=4)OC=3C3C=CC=CC=3)=CC=2)CCC1.C(OC(=O)[NH:36][C:37]1([C:41]2[CH:46]=[CH:45][C:44]([C:47]3[C:56](=[O:57])[C:55]4[C:50](=[CH:51][C:52]([O:59][CH3:60])=[C:53]([CH3:58])[CH:54]=4)[O:49][C:48]=3[C:61]3[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=3)=[CH:43][CH:42]=2)[CH2:40][CH2:39][CH2:38]1)(C)(C)C>>[NH2:36][C:37]1([C:41]2[CH:42]=[CH:43][C:44]([C:47]3[C:56](=[O:57])[C:55]4[C:50](=[CH:51][C:52]([O:59][CH3:60])=[C:53]([CH3:58])[CH:54]=4)[O:49][C:48]=3[C:61]3[CH:62]=[CH:63][CH:64]=[CH:65][CH:66]=3)=[CH:45][CH:46]=2)[CH2:38][CH2:39][CH2:40]1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(7-methoxy-6-methyl-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (46 mg, 0.090 mmol) was reacted to give the title compound (34 mg, 92%). LCMS (Method E): RT=3.85 min, [M+H]+=412. 1H NMR (400 MHz, DMSO-d6): δ 7.80 (s, 1H), 7.38-7.25 (m, 7H), 7.18 (s, 1H), 7.05 (d, J=9.6 Hz, 2H), 3.90 (s, 3H), 2.35-2.26 (m, 2H), 2.25-2.10 (m, 5H), 2.06-1.87 (m, 3H), 1.64-1.53 (m, 1H).