Thionyl Chloride → HCID 13340573, Verbindung

HRID 1037583Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1037583
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:14])=O>>[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([Cl:14])=[O:11])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 1372144-Iodophenylacetic acid

Produkt 1

HCID 13340573HCID 13340573, Verbindung

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Under an argon atmosphere, to 4-iodophenylacetic acid (11) (prepared by the process described in Chen, Q.-H. et al., Bioorg. Med. Chem. 14, 7898-7909 (2006)) (1.06 g, 4.05 mmol) was added thionyl chloride (5.00 mL, 68.6 mmol) and heated to reflux (100° C.) for 1.5 h. After cooling to room temperature, the mixture was concentrated under reduced pressure to give 4-iodophenylacetyl chloride (12) as a brown oily crude product, which was used in the next reaction without further purification.

Aufarbeitung

  1. temperatureheated
  2. temperatureAfter cooling to room temperature
  3. concentrationthe mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5d2d0b44fc0e41c5a968242015e9a317
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08546568B2

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