Methanesulfonic Acid → Eprosartan Mesylate

Beteiligte Stoffe

Reaktionsschritte

An embodiment of the present invention is as follows: eprosartan is dissolved or suspended in glacial acetic acid, then methanesulfonic acid is added and stirred to obtain a solution of eprosartan mesylate in glacial acetic acid, the precipitated solid is stirred and filtered to obtain a solid of eprosartan mesylate, or glaicial acetic acid is concentrated to dry to obtain a solid of eprosartan mesylate, or an organic ester solvent is added dropwise to the glacial acetic acid under stirring to precipitate crystal and separate to obtain a solid of eprosartan mesylate, wherein the ratio of eprosartan (mass, g): methanesulfonic acid (mass, g): glacial acetic acid (volume, ml) is 1:0.1-5.0:1-15, and the temperature of reaction is 10° C.-110° C.

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