Triethylamine → HCID 58379680, Verbindung

HRID 1038985Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1038985
[CH2:1]([NH:8][CH2:9][C:10]#[CH:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:19](Cl)(=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21]>C(Cl)Cl>[CH2:1]([N:8]([CH2:9][C:10]#[CH:11])[C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 62493Pivaloyl chlorideHCID 99277N-Propargylbenzylamine

Produkt 1

HCID 58379680HCID 58379680, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred solution of N-benzylprop-2-yn-1-amine (472 mg, 3.25 mmol) and triethylamine (493 mg, 4.88 mmol) in DCM (16 mL), cooled to 0° C. was added pivaloyl chloride (451 mg, 3.74 mmol). After 1 hour the reaction mixture was applied directly to the top of a silica gel column for purification, eluting with a gradient of 60-100% DCM in hexanes to give the title compound. MS: m/z=230 (M+1).

Aufarbeitung

  1. customAfter 1 hour the reaction mixture was applied directly to the top of a silica gel column for purification
  2. washeluting with a gradient of 60-100% DCM in hexanes

Quellen und Nachweise

ORD-Eintrag
ord-e0d97fc053e0446699b7338d6215cfbc
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08552023B2

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