Hydrazine → N-aminobenzenecarbothioamide

HRID 1039166

Reaktionsgleichung

Reaktionsgleichung von HRID 1039166
COC(=O)C[S:5][C:6](=S)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH2:15][NH2:16]>C(O)C>[C:6]([NH:15][NH2:16])(=[S:5])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 71356278Methyl 2-((phenylcarbonothioyl)thio)acetate

Produkt 1

HCID 3361911N-aminobenzenecarbothioamideAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Add a solution of thiobenzoylsulfanylacetic acid methyl ester (1.9 g, 8.4 mmol) in ethanol (30 mL) to a solution of anhydrous hydrazine (1 mL) at room temperature under nitrogen and stir for 2 hours. Then add water (20 mL) and remove the solvent under reduced pressure. Dissolve the residue in ethyl acetate (300 mL), wash with water (200 mL) and brine (200 mL), and dry over magnesium sulfate. Remove the solvent under reduced pressure to provide thiobenzoic acid hydrazide (1.2 g, 94%).

Aufarbeitung

  1. customThen add water (20 mL) and remove the solvent under reduced pressure
  2. dissolutionDissolve the residue in ethyl acetate (300 mL)
  3. washwash with water (200 mL) and brine (200 mL)
  4. dry with materialdry over magnesium sulfate
  5. customRemove the solvent under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e4fcfebd8f5843d19cbaa5f7df69b2d0
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08552039B2

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