Ethanol, reaction products with ammonia, distn. residues → 2-(2-Methyl-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)ethanamine

HRID 1039274Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1039274
[CH3:1][C:2]1[O:3][C:4]2[C:13]3[C:12](=[CH:14][C:15]#[N:16])[CH2:11][CH2:10][C:9]=3[CH:8]=[CH:7][C:5]=2[N:6]=1.N.C(O)C>C(O)C.[Co]>[CH3:1][C:2]1[O:3][C:4]2[C:13]3[C:12](=[CH:14][CH2:15][NH2:16])[CH2:11][CH2:10][C:9]=3[CH:8]=[CH:7][C:5]=2[N:6]=1

Komponenten

5

Edukt 2

HCID 22020343Ethanol, reaction products with ammonia, distn. residuesHCID 67353411(2-Methyl-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)acetonitrile

Produkt 1

HCID 673538152-(2-Methyl-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)ethanamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 104730CobaltKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of (2-methyl-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)acetonitrile (290 mg, 1.38 mmol) in ethanol (8 mL) were added Raney cobalt (3 g) and 2N ammonia/ethanol solution (4 mL), and the mixture was stirred at room temperature for 3 hr under a hydrogen atmosphere. The catalyst was filtered off using celite, and the filtrate was concentrated under reduced pressure to give the title compound. The obtained title compound was used for the reaction of Examples 3 and 5 without further purification.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-63f6eb55899c45e2827459afefc6a697
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08552037B2

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