N-[2-(6-Amino-7-methoxy-2,3-dihydro-1H-inden-1-ylidene)ethyl]acetamide → N-[2-(6-amino-7-methoxy-2,3-dihydro-1H-inden-1-yl)ethyl]acetamide

HRID 1039282Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1039282
[NH2:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]2[C:5]([CH2:6][CH2:7][C:8]2=[CH:13][CH2:14][NH:15][C:16](=[O:18])[CH3:17])=[CH:4][CH:3]=1>CO.[C].[Pd]>[NH2:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]2[C:5]([CH2:6][CH2:7][CH:8]2[CH2:13][CH2:14][NH:15][C:16](=[O:18])[CH3:17])=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 67352334N-[2-(6-Amino-7-methoxy-2,3-dihydro-1H-inden-1-ylidene)ethyl]acetamide

Produkt 1

HCID 57781264N-[2-(6-amino-7-methoxy-2,3-dihydro-1H-inden-1-yl)ethyl]acetamideAusbeute 96,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

N-[2-(6-Amino-7-methoxy-2,3-dihydro-1H-inden-1-ylidene)ethyl]acetamide (2.62 g, 10.7 mmol) was dissolved in methanol (50 mL), a 10% palladium-carbon powder (500 mg) was added, and the mixture was stirred at room temperature for 5 hr under a hydrogen atmosphere. The catalyst was filtered off using celite, and the filtrate was concentrated under reduced pressure to give the title compound (2.56 g, yield 96%).

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7a3358c76eb34b358c67fa3868d354f1
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08552037B2

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