Dichloromethane → 3-(1-(Dimethylamino)-2-methylpentan-3-yl)phenol hydrochloride

HRID 1040302Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1040302
[CH3:1][N:2]([CH3:16])[CH2:3][CH:4]([CH3:15])[CH:5]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7].[Cl:17]CCl>Cl.C(OC(C)C)(C)C>[ClH:17].[CH3:16][N:2]([CH3:1])[CH2:3][CH:4]([CH3:15])[CH:5]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7]

Komponenten

4

Edukt 2

HCID 6344DichloromethaneHCID 64330913-(1-(Dimethylamino)-2-methylpentan-3-yl)phenol

Produkt 1

HCID 231069343-(1-(Dimethylamino)-2-methylpentan-3-yl)phenol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21510344Isopropyl ether hydrochlorideLösungsmittel

Versuchsvorschrift

To stirred solution of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (4 g, 0.02 mol) in dichloromethane (20 ml), isopropyl ether hydrochloride (6 ml) was added at ambient temperature and stirred for 30 minutes. Solvents were distilled off from the reaction mixture. To the residue isopropyl ether (8 ml) was added and stirred for 15 minutes. Solvent was distilled off from the mixture to give 4.3 g of the title compound.

Aufarbeitung

  1. additionwas added at ambient temperature
  2. distillationSolvents were distilled off from the reaction mixture
  3. additionTo the residue isopropyl ether (8 ml) was added
  4. stirringstirred for 15 minutes
  5. distillationSolvent was distilled off from the mixture

Quellen und Nachweise

ORD-Eintrag
ord-d3d93c13df264a87a63513b0942b1daf
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08552219B2

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