Hydrochloric Acid → 2-Amino-3-chloro-5-fluorobenzoic acid

HRID 1041729Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1041729
[Cl:1][C:2]1[CH:3]=[C:4]([F:13])[CH:5]=[C:6]2[C:10]=1[NH:9]C(=O)[C:7]2=[O:12].[OH:14]O.Cl>[OH-].[Na+]>[NH2:9][C:10]1[C:2]([Cl:1])=[CH:3][C:4]([F:13])=[CH:5][C:6]=1[C:7]([OH:12])=[O:14]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 167936797-Chloro-5-fluoroindoline-2,3-dione

Produkt 1

HCID 289741482-Amino-3-chloro-5-fluorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A solution of 7-chloro-5-fluoro-1H-indole-2,3-dione (270 mg) in 1 M sodium hydroxide solution (5 mL) was treated with 30% hydrogen peroxide (5 mL) via dropwise addition. After one hour of stirring, the reaction was acidified with HCl to pH 1, and extracted three times with ethyl acetate. The combined organic layers were dried with sodium sulfate, and concentrated in vacuo to provide 200 mg of 2-amino-3-chloro-5-fluoro-benzoic acid.

Aufarbeitung

  1. extractionextracted three times with ethyl acetate
  2. dry with materialThe combined organic layers were dried with sodium sulfate
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0c31c0868b74449e943750cf469db363
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08552186B2

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