Dichloromethane → HCID 178511701, Verbindung
Reaktionsgleichung
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([O:14][C:15]2[CH:16]=[CH:17][C:18]3[N:19]([C:21]([C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH2:31][CH2:32][N:33]5[CH2:38][CH2:37][O:36][CH2:35][CH2:34]5)[CH:25]=4)=[N:22][N:23]=3)[CH:20]=2)[CH2:10][CH2:9]1)(C)(C)C.C(Cl)Cl.[C:43]([OH:49])([C:45]([F:48])([F:47])[F:46])=[O:44]>>[F:46][C:45]([F:48])([F:47])[C:43]([OH:49])=[O:44].[N:33]1([CH2:32][CH2:31][O:30][C:26]2[CH:25]=[C:24]([C:21]3[N:19]4[CH:20]=[C:15]([O:14][C@H:11]5[CH2:12][CH2:13][C@H:8]([NH2:7])[CH2:9][CH2:10]5)[CH:16]=[CH:17][C:18]4=[N:23][N:22]=3)[CH:29]=[CH:28][CH:27]=2)[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1Komponenten
4
Versuchsvorschrift
A solution of Example 14 step a (196 mg, 0.178 mmol) in TFA (2 mL) and DCM (10 mL) was stirred at RT for 0.5 H, then concentrated in vacuo to give the title compound (quantitative yield). LCMS (Method 2): Rt 0.38 min, m/z 438 [M-CF3CO2+].
Aufarbeitung
- concentrationconcentrated in vacuo