Cyanuric chloride → Tert-butyl ((2r,5s,7as)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate

HRID 10425

Reaktionsgleichung

Reaktionsgleichung von HRID 10425
[C:1]([C@@H:4]1[CH2:11][CH2:10][C@@H:9]2[N:5]1[C:6](=[O:20])[C@H:7]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:8]2)(=O)[NH2:2].N1C(Cl)=NC(Cl)=NC=1Cl>CN(C)C=O>[C:1]([C@@H:4]1[CH2:11][CH2:10][C@@H:9]2[N:5]1[C:6](=[O:20])[C@H:7]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:8]2)#[N:2]

Komponenten

4

Edukt 2

HCID 7954Cyanuric chlorideHCID 90895673HCID 90895673, Verbindung

Produkt 1

HCID 91321587Tert-butyl ((2r,5s,7as)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

100 mg of tert-butyl ((2R,5S,7aS)-5-carbamoyl-3-oxohexahydropyrrolizin-2-yl)carbamate were dissolved in 2 ml of dimethylformamide, and 65 mg of cyanuric chloride were added. The mixture was stirred for 3 h, and the dimethylformamide was removed in vacuo. The residue was chromatographed on silica gel.

Aufarbeitung

  1. customthe dimethylformamide was removed in vacuo
  2. customThe residue was chromatographed on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-93eff2bf0daa450c897e724582f37625
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094800B2

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