Triethylamine → HCID 178453336, Verbindung

HRID 1042604Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1042604
C(OC([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[N:10]=[CH:9]1)=O)(C)(C)C.C(N(CC)CC)C>CO>[C:19]([O:18][C:16](=[O:17])[NH:15][CH2:14][CH2:13][C:11]1[N:10]=[CH:9][NH:8][CH:12]=1)([CH3:22])([CH3:20])[CH3:21]

Komponenten

4

Edukt 2

HCID 8471TriethylamineHCID 819122tert-butyl 4-{2-[(tert-butoxycarbonyl)amino]ethyl}-1H-imidazole-1-carboxylate

Produkt 1

HCID 178453336HCID 178453336, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To 4-(2-tert-Butoxycarbonylamino-ethyl)-imidazole-1-carboxylic acid tert-butyl ester, were added 100 mL of methanol and 800 mL (5.73 mol) of triethylamine. The reaction mixture was allowed to stir at room temperature for four days and concentrated to oil. To the residue were added 40 mL of ether and 80 mL of hexane. This mixture was allowed to stand at room temperature resulting in precipitation of product, as a white solid, which were collected. The yield was 1.7 g (8.0 mmol, 40%) (LC/MS M+H 212.1).

Aufarbeitung

  1. concentrationconcentrated to oil
  2. additionTo the residue were added 40 mL of ether and 80 mL of hexane
  3. customto stand at room temperature
  4. customresulting in precipitation of product, as a white solid, which
  5. customwere collected

Quellen und Nachweise

ORD-Eintrag
ord-ea7f02024f5c4e3e99dea81d3be5ad68
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08557989B2

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